Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Abstract Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells.Whether pyroptosis can be a death form of MC remains unknown.Proteasome-mediated protein degradation is crucial for M-phase.Bortezomib (BTZ), which inhibits the 20S catalytic particle of proteasome, is ap