SYNERGISTIC INDUCTION OF MITOTIC PYROPTOSIS AND TUMOR REMISSION BY INHIBITING PROTEASOME AND WEE FAMILY KINASES

Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

Abstract Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells.Whether pyroptosis can be a death form of MC remains unknown.Proteasome-mediated protein degradation is crucial for M-phase.Bortezomib (BTZ), which inhibits the 20S catalytic particle of proteasome, is ap

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The impact of anionic polymers on gene delivery: how composition and assembly help evading the toxicity-efficiency dilemma

Abstract Cationic polymers have been widely studied for non-viral gene delivery due to their ability to bind genetic material and to interact with cellular membranes.However, their charged nature carries the canals & nubiola cava risk of increased cytotoxicity and interaction with serum proteins, limiting their potential in vivo application.Therefo

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Burden of soil-transmitted helminth infection in pregnant refugees and migrants on the Thailand-Myanmar border: Results from a retrospective cohort.

BackgroundSoil-transmitted helminth (STH) infections are widespread in tropical and subtropical regions.While many STH infections are asymptomatic, vulnerable populations such as pregnant women face repercussions such as aggravation of maternal anaemia.However, data on prevalence and the effect of STH infections in pregnancy are limited.The aim of

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